Hardest Video Game Boss/Enemy

[retrolinkx]

Oh Come on Vamp was easy once Noami told you about your syringe that suppresses Nano machines.

If you were listening, you would've heard that [spoiler]Vamp can't die because his nano machines help him recover faster, so that nothing could kill him, you then learn that you have a syringe to suppress nano machines in your body, and can be used as a weapon. Noami even told you during the battle.[/spoiler]

He was easy once you knew that, unless you were playing on hard.

To be honest, most MGS bosses aren't hard, just need to know how to beat them, and then trail and error.

The final boss in Bayonetta was hard, I remember failing 3 times when I had her health down to low because the bottom of the arena was start sucking me in which was an instakill, and I had to start ALL over again.